Orally disintegrating tablets and bitterness-suppressing preparations containing risperidone

摘要

Disclosed are: an orally disintegrating tablet; and a bitter-blocking preparation, each of which comprises risperidone. It is found that an orally disintegrating table having good disintegration property and ensured hardness can be produced by compressing and shaping a powder comprising risperidone, crystalline cellulose, an inorganic excipient, carmellose, and a lubricating agent in an amount of 0.8 wt% or less, preferably 0.5 wt% or less, more preferably 0.1 wt% or less per one tablet. Specifically disclosed are: a powdery/granular preparation produced by granulating an excipient and/or a disintegrating agent with a solution having a bitter-blocking base material dissolved and/or suspended therein and also having risperidone having a solubility in water of 1 g/mL or less (at 20°C) dissolved or suspended therein; and a tablet produced by tabletting the powdery/granular preparation. The powdery/granule preparation and the tablet can block a bitter taste of risperidone.