Marble bone disease onset model non-human animal

摘要

PROBLEM TO BE SOLVED: To provide a non-human animal developing osteopetrosis by trouble in differentiation induction of bone marrow cell to osteoclast, and to provide a method for screening a substance promoting or suppressing differentiation induction of bone marrow cell to osteoclast, and the like, by using the osteopetrosis onset model non-human animal.;SOLUTION: A double knockout non-human animal (DKO) defected in gene function is obtained by defecting or mutating a gene coding membrane adaptor molecule DNAX activating protein DAP12 supporting immunologically activating signal transfer and a gene encoding Fc acceptor common γ subunit FcRγ. The differentiation induction-promoting or suppressing substance of bone marrow cell to osteoclast, or, bone metabolism promoting or suppressing substance is screened by using osteopetrosis onset DAP 12 and FcRγ gene double knockout non-human animal.;COPYRIGHT: (C)2006,JPO&NCIPI