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Novel protein and preventive / therapeutic agent for neurodegenerative diseases such as polyglutamine disease using the same
Novel protein and preventive / therapeutic agent for neurodegenerative diseases such as polyglutamine disease using the same
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机译:新型蛋白质和用于神经退行性疾病(例如聚谷氨酰胺病)的预防/治疗剂
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摘要
To provide a novel protein that can be a preventive/remedy in neurodegenerative diseases such as polyglutamine diseases based on the finding obtained by revealing the relationship between transcriptional dysfunction and neuronal death. Disclosed is a protein that is one of the following proteins (a) and (b). (a) A protein including an amino acid sequence represented by any one of SEQ ID NOS:1 to 3. (b) A protein including an amino acid sequence in which one to several amino acids are deleted, substituted or added in the amino acid sequence of (a), the protein having a dominant negative effect on a transcriptional activation factor YAP.
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机译:根据揭示转录功能障碍和神经元死亡之间关系的发现,提供一种可以预防/治疗诸如聚谷氨酰胺等神经变性疾病的新型蛋白质。公开了一种蛋白质,其是以下蛋白质(a)和(b)之一。(a)一种蛋白质,其包含由SEQ ID NOS:1至3中的任一个表示的氨基酸序列。(b)一种蛋白质,其包含在(a)的氨基酸序列中缺失,取代或添加一个或多个氨基酸的氨基酸序列,该蛋白质对转录激活因子YAP具有显着的负作用。
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