Oxidation method of unfractionated heparin and detection of presence or absence of glycoserine in heparin and heparin products

摘要

The invention relates to a method for determining the glycoserine content of a sample of a heparin or a heparin product, comprising depolymerizing the sample with at least one heparinase and analyzing the sample using a chromatography process to detect the presence or absence of glycoserine and/or oxidized glycoserine residues in the sample, wherein said chromatography process detects acetylated groups.