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High relaxivity contrast agent for magnetic resonance imaging (MRI) comprising a chelating moiety having a polyhydroxylated substituent
High relaxivity contrast agent for magnetic resonance imaging (MRI) comprising a chelating moiety having a polyhydroxylated substituent
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机译:用于磁共振成像(MRI)的高弛豫性造影剂,其包含具有多羟基取代基的螯合部分
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摘要
The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.
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