Method for producing reveromycin A or a synthetic intermediate thereof, method for producing spiroketal ring-containing compound, and novel anticancer agent, antifungal agent, and bone disease therapeutic agent

摘要

Expression of revQ gene which is a Streptomyces bacterium having the ability to produce reveromycin A or a synthetic intermediate thereof and which encodes the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having 80% or more identity with the amino acid sequence Is a Streptomyces bacterium that has been modified so as to increase compared to the parent strain, whereby the production ability is improved over that of the parent strain.