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Drug transporter to sentinel lymph node

机译:药物转运到前哨淋巴结

摘要

In the body, cancer cells are likely to metastasize, or drugs that specifically detect or treat lymph nodes that have already been confirmed to have small cancer metastasis, especially sentinel lymph nodes, can reach selectively, or the primary tumor site Drug transporter that can selectively and efficiently reach the drugs used for treatment to the surrounding tissues, is safe and minimally invasive, can reduce the burden on patients, and can reliably treat cancer diseases To do. The drug transporter is an anti-ICAM-1 antibody that binds to ICAM-1 expressed on lymph node endothelial cells, and is at least one of a fluorescent labeling agent, a radioisotope-containing labeling agent, a contrast agent, and an anticancer agent. While being chemically modified with a drug, it is contained as an active ingredient for drug transport.
机译:在体内,癌细胞可能会转移,或者特异性检测或治疗已被证实具有小癌转移的淋巴结的药物(尤其是前哨淋巴结)可以选择性地到达,或者可以选择性转移的主要肿瘤部位药物转运体并能有效地将药物用于周围组织,安全且微创,可减轻患者负担,并能可靠地治疗癌症。药物转运蛋白是与淋巴结内皮细胞上表达的ICAM-1结合的抗ICAM-1抗体,并且是荧光标记剂,含放射性同位素的标记剂,造影剂和抗癌剂中的至少一种。 。在用药物进行化学修饰的同时,它也被用作药物运输的活性成分。

著录项

  • 公开/公告号JPWO2012002388A1

    专利类型

  • 公开/公告日2013-08-29

    原文格式PDF

  • 申请/专利权人 国立大学法人信州大学;

    申请/专利号JP20120522643

  • 发明设计人 大橋 俊夫;河合 佳子;

    申请日2011-06-28

  • 分类号A61K39/395;A61K47/48;A61K9/14;A61P35;A61K49;A61K51;A61K45;

  • 国家 JP

  • 入库时间 2022-08-21 16:54:19

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