Device used to it and crystallization conditions exploration method of biopolymers

摘要

How to explore the conditions by changing continuously or intermittently the physicochemical properties of the biopolymer-containing solution under the condition that biopolymers such as proteins are present in a monodisperse state in a stable, biopolymers crystallized A method and apparatus the method comprising, can perform a change of physicochemical properties while maintaining as much as possible homogeneity of the biopolymer-containing solution. And intermittently or continuously the concentration of at least one substance (hereinafter, referred to as the reagent) of at least the flow of the solution in the circulation passage, altering the physicochemical properties of the solution and the biopolymer in the solution includes that by monitoring continuously or intermittently crystal formation in solution and varied while maintaining constant the capacity of the circulation flow path, to explore the conditions under which crystals of the biopolymer is produced, With the solution injection into the circulation flow path, the capacity of the circulation flow path is kept constant by discharging the flow channel out through the semi-permeable membrane, a portion of the solution in the channel , crystal formation conditions exploration method of biopolymers. Apparatus used in this exploration method.