The aromatic compound, and the qualification substrate for oligonucleotide derivative synthesis which uses that, the oligonucleotide derivative and oligonucleotide construction ones

摘要

Topic 3 ' the skeleton of the inside two of the benzene skeleton and the pyridine skeleton chemistry synthesizing the oligonucleotide derivative qualification easily is possible in the end, furthermore the aromatic compound which becomes the oligonucleotide derivative which at the little can synthesize easily number of processes, and the precursive body in order to prepare the qualification substrate for that oligonucleotide derivative synthesis is offered. In addition, 3 ' the skeleton of the inside two of the benzene skeleton and the pyridine skeleton chemistry being the oligonucleotide derivative qualification in the terminal dangling end, permeability to the cell membrane being satisfactory, the oligonucleotide derivative and oligonucleotide construction ones which possess the nuclease tolerance which is superior are offered.SolutionsThe unit which with the below-mentioned constitutional formula (a) is shown through linkage editor, the qualification substrate for oligonucleotide derivative synthesis which features that chemistry it is qualification (however, R in formula - R becoming independent respectively, show the substituent other than hydrogen or hydrogen in the substrate. In addition, in Z formula and Z becoming independent respectively, it shows CH or nitrogen, X shows oxygen or the sulfur). Choice figure Drawing 8