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Five acetic acid derivatives and diethylenetriamine manufacturing method of your acetic acid derivatives of diethylenetriamine
Five acetic acid derivatives and diethylenetriamine manufacturing method of your acetic acid derivatives of diethylenetriamine
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机译:乙二胺的乙酸衍生物的五种乙酸衍生物和二乙三胺的制造方法
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摘要
A method for producing simply and efficiently intermediate compounds for the synthesis of gadolinium complex of substituents for improving the organ specificity and retention in blood has been introduced, the present invention was prepared by the method and an object thereof is to provide a synthetic intermediate. Step to remove excess allyl halide compound; reacting the allyl halide compound pentaacetic acid pentaester diethylenetriamine manufacturing method pentaacetic acid derivative diethylenetriamine according to the present invention (I) are and, solvent, diethylenetriaminepentaacetic acid and comprising a step of reacting a base with the reaction product of an allyl halide compound and penta esters.Wherein, R 1 ~R 5 is a C 1-6 alkyl group independently]
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机译:引入了一种简单有效地制备中间体化合物的方法,该中间体化合物用于合成取代基的ado络合物以改善器官特异性和在血液中的保留,通过该方法制备了本发明,其目的是提供一种合成中间体。步骤去除过量的烯丙基卤化合物;使烯丙基卤化物与五乙酸五酯二亚乙基三胺反应制备方法根据本发明(I)的五乙酸衍生物二亚乙基三胺为溶剂,二亚乙基三胺五乙酸,并包括使碱与烯丙基卤化物和五酯的反应产物反应的步骤。其中 Sub> R 1 〜R 5 Sub>是独立的 C 1-6 Sub>烷基]
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