SMALL NON-CODING REGULARTORY RNA's and METHODS FOR THEIR USE

摘要

Disclosed are methods and compositions related to small, non-coding RNA molecules having gene regulatory activity, compositions comprising same, and methods for their use. Provided are isolated small non-coding RNA molecules transcribed from an intergenic region of the human genome, wherein the intergenic region contains at least one small nucleotide polymorphism (SNP) associated with one or more human diseases or disorders. Also disclosed are methods for the detection of these small non-coding RNA molecules in a biological sample and related therapeutic, diagnostic, and prognostic methods.