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TOPICAL RAPAMYCIN FOR TREATMENT OF FACIAL ANGIOFIBROMAS IN TUBEROUS SCLEROSIS

机译：局部雷帕霉素用于治疗顽固性硬化症的面部血管纤维瘤

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摘要

The present disclosure provides for a method and a topical composition to treat facial angiofibromas in Tuberous Sclerosis by applying from about 0.25% to about 2% rapamycin to a small body surface area.

机译：本公开提供了通过将约 0.25 ％至约 2 ％的雷帕霉素施用于小的身体表面积来治疗结节性硬化症中的面部血管纤维瘤的方法和局部用组合物。 展开▼

著录项

公开/公告号US2013225630A1

专利类型

公开/公告日2013-08-29

原文格式PDF

申请/专利权人 JOYCE M.C. TENG;ANNA K. HAEMEL;MARLA J. AHLGRIMM;
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申请/专利号US201313852773

发明设计人 JOYCE M.C. TENG;ANNA K. HAEMEL;MARLA J. AHLGRIMM;
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申请日2013-03-28

分类号A61K31/439;

国家 US

入库时间 2022-08-21 16:50:26

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1. 局部雷帕霉素制剂及其在治疗面部血管纤维瘤和其他皮肤病中的用途 [P] . 中国专利： CN113710232A . 2021-11-26

2. 一种治疗结节性硬化症血管纤维瘤药物的制备方法 [P] . 中国专利： CN113181367A . 2021-07-30

3. TOPICAL RAPAMYCIN FOR TREATMENT OF FACIAL ANGIOFIBROMAS IN TUBEROUS SCLEROSIS [P] . 美国专利： US2013225631A1 . 2013-08-29

机译：局部雷帕霉素用于治疗顽固性硬化症的面部血管纤维瘤

4. TOPICAL RAPAMYCIN FOR TREATMENT OF FACIAL ANGIOFIBROMAS IN TUBEROUS SCLEROSIS [P] . 美国专利： US2012022095A1 . 2012-01-26

机译：局部雷帕霉素用于治疗顽固性硬化症的面部血管纤维瘤

5. Topical rapamycin formulations and their use in facial angiofibromas and other skin disorders [P] . KR20210130769A . 2021-11-01

机译：局部雷帕霉素配方及其在面部血管纤维瘤和其他皮肤病中的用途

1. Combined Treatment with Electrocauterization,Carbon Dioxide Laser,and Microneedle Fractional Radiofrequency for Facial Angiofibromas in Tuberous Sclerosis Complex:A Case Report and Literature Review [J] . Jiying DONG, Shen WANG, Min YAN, 中国整形与重建外科(英文) . 2021,第001期

2. Combined Treatment with Electrocauterization, Carbon Dioxide Laser, and Microneedle Fractional Radiofrequency for Facial Angiofibromas in Tuberous Sclerosis Complex: A Case Report and Literature Review [J] . Jiying DONG, Shen WANG, Min YAN, 中国整形与重建外科（英文） . 2021,第001期

3. Tuberous Sclerosis Complex Associated with Autism Spectrum Features and Bumetanide as a Pharmacological Indication: A Case Report [J] . Maria Cristina Brió, Mariana Fazzina, Melina Chindi 精神病学期刊（英文） . 2021,第003期

4. Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for the Treatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From a Single-Center, Open-Label Trial [J] . Margaret C. Wheless, Apana A. Takwi, Hassan Almoazen, Child Neurology Open . 2019,第3期

5. Efficacy and Safety of Topical Rapamycin in Patients With Facial Angiofibromas Secondary to Tuberous Sclerosis ComplexThe TREATMENT Randomized Clinical Trial [J] . Mary Kay?Koenig, Cynthia S.?Bell, Adelaide A.?Hebert, JAMA dermatology . 2018,第7期

6. Analysis of current data on the use of topical rapamycin in the treatment of facial angiofibromas in Tuberous Sclerosis Complex [J] . Balestri R., Neri I., Patrizi A., Journal of the European Academy of Dermatology and Venereology: JEADV . 2015,第1期

7. Machine Learning in Epilepsy Drug Treatment Outcome Prediction Using Multi-modality Data in Children with Tuberous Sclerosis Complex [C] . Jun Yang, Cailei Zhao, Shi Su, International Conference on Big Data and Information Analytics . 2020

8. A Comprehensive Analysis of Tuberous Sclerosis Complex [D] . Fager, Rachel L. 2021

9. Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for theTreatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From aSingle-Center Open-Label Trial [O] . Margaret C. Wheless, Apana A. Takwi, Hassan Almoazen, 2019

10. Efficacy and Safety of Topical Rapamycin in Patients With Facial Angiofibromas Secondary to Tuberous Sclerosis Complex [O] . Mary Kay Koenig, Cynthia S. Bell, Adelaide A. Hebert, 2018

11. Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex. [R] . Koenig, M. K. 2015

1. Angiographic and volumetric effects of mammalian target of rapamycin inhibitors on angiomyolipomas in tuberous sclerosis [J] . Rahul A Sheth ,Adam S Feldman ,Elahna Paul . 世界放射学杂志：英文版（电子版） . 2016,第3期

2. Potential for treatment of severe autism in tuberous sclerosis complex [J] . Tanjala T Gipson ,Gwendolyn Gerner ,Mary Ann Wilson . 世界临床儿科杂志 . 2013,第3期

3. 平阳霉素局部注射治疗口腔颌面部血管瘤 [C] . 雷文 . 第八届全国临床医药学术会议 . 1999

4. 长期雷帕霉素治疗对结节性硬化症患儿血清脂质及脂肪酸氧化的影响 [A] . 庞领玉 . 2016