NOVEL CANNABINOID RECEPTOR 2 (CB2) INVERSE AGONISTS AND THERAPEUTIC POTENTIAL FOR MULTIPLE MYELOMA AND OSTEOPOROSIS BONE DISEASES

摘要

Cannabionid receptor-2 inverse antagonists include compounds represented by Formula IV, or a pharmaceutically acceptable salt thereof:; ;wherein: R¹ and R² are independently H, alkyl, or alkenyl; R³ is alkyl, alkenyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl; R⁴ and R⁵ are independently a bond, alkylenyl, or alkenylenyl; each R⁶ and R⁷ is independently selected from the group consisting of OH, F, Cl, Br, I, (C₁-C₆)alkyl, alkoxy, amino, COOH, CONH₂, SO₃H, PO₃H₂, CN, SH, NO₂ and CF₃; and p and q are independently 0, 1, 2, 3, 4, or 5. Such compounds may be used to treat osteoporosis or multiple myeloma.