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METHODS FOR MODULATING SKELETAL REMODELING AND PATTERNING BY MODULATING SHN2 ACTIVITY, SHN3 ACTIVITY, OR SHN2 AND SHN3 ACTIVITY IN COMBINATION
METHODS FOR MODULATING SKELETAL REMODELING AND PATTERNING BY MODULATING SHN2 ACTIVITY, SHN3 ACTIVITY, OR SHN2 AND SHN3 ACTIVITY IN COMBINATION
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机译:通过组合调节SHN2活性,SHN3活性或SHN2和SHN3活性来调节骨骼重塑和模式的方法
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摘要
This invention is based, at least in part, on the discovery that Shn2 and Shn3 play an important role in skeletal remodeling and skeletal patterning. Accordingly, the present invention provides methods for identifying medulators of Shn2 activity and methods for modulating bone formation and mineralization and Shn2-associated disorders using agents that modulate Shn2 expression and/or activity, in addition to methods for modulating Shn2 and Shn3.
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