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OLIGONUCLEOTIDES WHICH INHIBIT P53 INDUCTION IN RESPONSE TO CELLULAR STRESS
OLIGONUCLEOTIDES WHICH INHIBIT P53 INDUCTION IN RESPONSE TO CELLULAR STRESS
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机译:抑制P53诱导细胞应激的寡核苷酸
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摘要
The present invention relates to novel oligonucleotides which comprise p53 5′-UTR sequence TCCCTGG (SEQ ID NO: 1) or the complementary p53 3′-UTR sequence CCAGGGA (SEQ ID NO: 2) and their use for such therapeutic applications as protection of normal tissues from the toxicities of chemical or radiation exposure; reducing tissue damage in hypoxia-reperfusion injury, neurodegenerative disorders, oxidative stress, injuries, hyperthermia; preventing aging; preservation of tissues and organs prior to transplanting, etc.
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机译:本发明涉及包含p53 5′-UTR序列TCCCTGG(SEQ ID NO:1)或互补p53 3′-UTR序列CCAGGGA(SEQ ID NO:2)的新型寡核苷酸,以及它们在治疗应用中的用途,如保护p53。正常组织免受化学或放射线照射的毒性;减少缺氧-再灌注损伤,神经退行性疾病,氧化应激,损伤,体温过高引起的组织损伤;防止老化;移植前保存组织器官等
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