首页> 外国专利> Suspension containing hydronium stabilized colloidal silicic acid nanoparticles, formulation obtained from the said diluted suspension, powder obtained from the said de-hydrated suspension, compositions obtained from the said powder, preparation and use

Suspension containing hydronium stabilized colloidal silicic acid nanoparticles, formulation obtained from the said diluted suspension, powder obtained from the said de-hydrated suspension, compositions obtained from the said powder, preparation and use

机译:含有水合氢稳定的胶态硅酸纳米颗粒的悬浮液,由所述稀释的悬浮液获得的制剂,由所述脱水的悬浮液获得的粉末,由所述粉末获得的组合物,制备和用途

摘要

The present invention relates to hydronium stabilized silicic acid nanoparticles, to the formulation obtained from the said diluted suspension, to the powder obtained from the said dehydrated suspension and to the preparation or dosage form obtained from the said suspension, formulation or powder, to their preparation and their use in all kinds of applications in the domains of food, medicine, pharmaceutics, cosmetics. The present invention provides a stable suspension of colloidal silicic acid nanoparticles having a pH lower than 0.9, a molar silicon concentration between 0.035 and 0.65, a free water concentration of at least 30% (w/v) and a ratio between hydronium ion and Si molar concentrations higher than 2 and preferably inferior to 4. The present invention further provides a method for preparing a stable suspension of colloidal silicic acid nanoparticles, which comprises the steps of providing an aqueous inorganic or organic silicon solution and quick mixing said aqueous inorganic or organic silicon solution with water containing a strong acidic compound at a temperature inferior at 30° C., preferably comprised between 1 and 25° C., to form a suspension of colloidal silicic acid nanoparticles having a pH lower than 0.9, stabilized by hydronium ions, the ratio between hydronium ions and Si molar concentrations being higher than 2 and preferably inferior to 4, for a molar silicon concentration between 0.035 and 0.65 and a free water concentration of at least 30% (w/v).
机译:本发明涉及水合氢稳定的硅酸纳米颗粒,由所述稀释的悬浮液获得的制剂,由所述脱水的悬浮液获得的粉末,以及由所述悬浮液,制剂或粉末获得的制剂或剂型,及其制备方法及其在食品,医药,制药,化妆品领域的各种应用中的使用。本发明提供了pH低于0.9,硅的摩尔浓度为0.035至0.65,游离水浓度为至少30%(w / v)以及水合氢离子与Si之比的胶态硅酸纳米颗粒的稳定悬浮液。摩尔浓度高于2且优选低于4。在低于30°C的温度下(最好包含1至25°C的温度)与含有强酸性化合物的水形成硅溶液,形成pH值低于0.9的胶态硅酸纳米颗粒的悬浮液,并通过水合氢离子稳定化,对于硅的摩尔浓度,水合氢离子与Si摩尔浓度之比大于2,优选小于4。介于0.035和0.65之间,游离水浓度至少为30%(w / v)。

著录项

  • 公开/公告号US8563072B2

    专利类型

  • 公开/公告日2013-10-22

    原文格式PDF

  • 申请/专利权人 IVO SUVEE;GUILLAUME TOURGIS;

    申请/专利号US20090988183

  • 发明设计人 IVO SUVEE;GUILLAUME TOURGIS;

    申请日2009-04-16

  • 分类号A23L1/30;A61K9/48;A61K33;A01N59;A01N55;A61K31/695;

  • 国家 US

  • 入库时间 2022-08-21 16:46:34

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