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CRH and POMC effects on animal growth

机译:CRH和POMC对动物生长的影响

摘要

The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily gain, shipping weight, end of test rib eye area, and adjusted weaning weight which is a measure of post-natal growth, based on the knowledge of their CRH, POMC and MC4R genotypes. The predictive value comes from the discovery that certain single nucleotide polymorphisms (SNPs) in these genes are linked to higher growth rate phenotypes. Specifically, the phenotypes that correlated with specific SNP's are end-of-test rib-eye area, adjusted weaning weight, average daily gain, shipping weight and hot carcass weight. The invention also provides novel kits that can be used in making the determination of these genotypes. The invention further provides for methods of screening bovines to predict which animals will have higher growth rate, allowing producers to selectively breed and manage animals based on desired characteristics, thereby maximizing productivity and profitability in commercial meat production operations.
机译:本发明提供了将显示出与生长速率增加相关的表型的牛动物的选择。这些表型包括热hot体重量,平均日增重,运输重量,测试肋眼区域的末端以及根据其CRH,POMC和MC4R基因型的知识而进行的调整后的断奶体重,这是衡量出生后生长的指标。预测价值来自以下发现:这些基因中的某些单核苷酸多态性(SNP)与更高的生长速度表型有关。具体而言,与特定SNP相关的表型为测试结束时的肋眼面积,调整后的断奶体重,平均日增重,运输重量和hot体重量。本发明还提供了可用于确定这些基因型的新颖试剂盒。本发明进一步提供了筛选牛的方法以预测哪些动物将具有更高的生长速度,从而允许生产者根据期望的特征选择性地繁殖和管理动物,从而使商业肉类生产操作中的生产率和利润最大化。

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