首页> 外国专利> 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-varicella zoster virus agents and methods of use

5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-varicella zoster virus agents and methods of use

机译：5-（ E ）-溴乙烯基尿嘧啶类似物和相关嘧啶核苷作为抗水痘带状疱疹病毒的药物及其使用方法

展开▼

页面导航

摘要

著录项

相似文献

摘要

The present invention relates to prodrug forms of β-L-1-[5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)]uracil (L-BHDU) and their use to treat viral infections of Varicella Zoster Virus, including recurrent VZV (shingles), especially including drug resistant Varicella Zoster Virus and related complications of this viral infection such as rash or post-herpetic neuralgia. 展开▼

机译：本发明涉及β-L-1-[5-（E-2-溴乙烯基）-2-（羟甲基）-1,3-二氧戊环-4-基）]尿嘧啶（L-BHDU）的前药形式。用于治疗水痘带状疱疹病毒的病毒感染，包括复发的VZV（带状疱疹），尤其是耐药性水痘带状疱疹病毒和这种病毒感染的相关并发症，例如皮疹或疱疹后神经痛。展开▼

著录项

公开/公告号US8492362B1

专利类型

公开/公告日2013-07-23

原文格式PDF

申请/专利权人 CHUNG K. CHU;
展开▼

申请/专利号US201113291512

发明设计人 CHUNG K. CHU;
展开▼

申请日2011-11-08

分类号A01N43/04;A61K31/70;

国家 US

入库时间 2022-08-21 16:45:52

相似文献

专利

外文文献

中文文献

1. 5－(E)－溴乙烯基尿嘧啶类似物和相关的嘧啶核苷作抗病毒剂及其使用方法 [P] . 中国专利： CN1420773A . 2003-05-28

2. 一种合成5-((E)-2-溴乙烯基)-2′-脱氧尿嘧啶核苷(溴呋啶)的方法 [P] . 中国专利： CN102432655A . 2012-05-02

3. 5-(E)-BROMOVINYL URACIL ANALOGUES AND RELATED PYRIMIDINE NUCLEOSIDES AS ANTI-VIRAL AGENTS AND METHODS OF USE [P] . CA2378370C . 2010-01-26

机译： 5-（E）-溴乙烯尿嘧啶类似物和相关的嘧啶核苷类作为抗病毒剂及其使用方法

4. 5-(E)-BROMOVINYL URACIL ANALOGUES AND RELATED PYRIMIDINE NUCLEOSIDES AS ANTI-VIRAL AGENTS AND METHODS OF USE [P] . 欧洲知识产权局专利： EP1204415B1 . 2010-09-08

机译： 5-（E）-溴乙烯尿嘧啶类似物和相关的嘧啶核苷类作为抗病毒剂及其使用方法

5. 5-(E)-bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use [P] . 美国专利： US2004053891A1 . 2004-03-18

机译： 5-（E）-溴乙烯基尿嘧啶类似物和相关嘧啶核苷作为抗病毒剂及其使用方法

1. Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses. [J] . Choi Y, Li L, Grill S, Journal of Medicinal Chemistry . 2000,第13期

2. Insecticidal activity of the pyrimidine nucleoside analogue (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) [J] . Michael Breuer, Arnold De Loof, Jan Balzarini, Pest Management Science . 2005,第8期

3. Dipeptidyl Peptidase IV-Activated Prodrugs of Anti-Varicella Zoster Virus Bicyclic Nucleoside Analogues Containing Different Self-Cleavage Spacer Systems [J] . Alberto Diez-Torrubia, Silvia Cabrera, Ingrid De Meester ChemMedChem . 2012,第9期

4. Electrochemical Impedance Evaluation of Uracil and Thymine Pyrimidine Derivatives and its Nucleosides Compounds as a Non-toxic Corrosion Inhibitors of Steels in 1M HCl [C] . Araceli Espinoza-Vazquez, Guillermo E. Negron-Silva, Deyanira Angeles Beltran, MES 26: Electrochemistry as a tool for sustainable development . 2011

5. Purine and pyrimidine carbocyclic nucleosides as antiviral agents. [D] . Bailey, Elaine LeCreurer. 2004

6. The bioavailability and disposition of 1-(beta-D-arabinofuranosyl)-5-(1-propynyl)uracil (882C87) a potent new anti-varicella zoster virus agent. [O] . R W Peck, R Wootton, D R Lee, 1995

7. The bioavailability and disposition of 1-(beta-D-arabinofuranosyl)-5-(1-propynyl)uracil (882C87), a potent, new anti-varicella zoster virus agent. [O] . Peck, R W, Wootton, R, Lee, D R, 1995

1. Efficient Synthesis of a New Class of iN/i-Nucleosides of 4iH/i-Thiochromeno2,3-id/ipyrimidine-10-Sulfone as Potential Anticancer and Antibacterial Agents [J] . Abdulrahman G. Alshammari ,Abdel-Rhman B. A. El-Gazzar ,Hend N. Hafez . 有机化学国际期刊（英文） . 2013,第3期

2. Corticosteroid and nucleoside analogue for hepatitis B virus-related acute liver failure [J] . Keiichi Fujiwara ,Shin Yasui ,Osamu Yokosuka . 世界胃肠病学杂志：英文版 . 2015,第36期

3. Effects of two novel nucleoside analogues on different hepatitis B virus promoters [J] . Xing-Xing He Ju-Sheng Lin Ying Chang Ying-Hui Zhang Yan Li Xiao-Yan Wang Dong Xu Xiao-Ming Cheng . 世界胃肠病学杂志：英文版 . 2008,第12期

4. Inhibition of hepatitis B virus by a novel L-nucleoside,β-L-D4A and related analogues [J] . Jin-MingWu ,Ju-ShengLin ,NaXie . 世界胃肠病学杂志：英文版 . 2003,第8期

5. 以磺胺嘧啶为载体的氟尿嘧啶靶向药物抗鼠H22肝癌实验研究 [C] . 胡喜钢 ,汪森明 ,张积仁 . 第14届世界冷冻治疗大会暨第一届国际冷冻免疫学大会、第三届中国肿瘤靶向治疗大会 . 2007

6. 5-溴脱氧尿嘧啶核苷对成人骨髓间充质干细胞体外标记的研究 [A] . 王小蕊 . 2008