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Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes
Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes
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机译:d 8 Sup>或d 10 Sup>金属络合物的无标记光学传感和生物分子表征
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摘要
The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal-metal interactions, π . . . π interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, using a composition comprising a charged d8 or d10 metal complex.
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