(20R,25S)-2-Methylene-19,26-Dinor-1α,25-Dihydroxyvitamin D₃ in crystalline form

摘要

A method of purifying (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D₃ to obtain (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D₃ in crystalline form. The method includes the steps of preparing a solvent of methanol and water, dissolving a product containing (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D₃ to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D₃ crystals, and recovering the (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D₃ crystals.