首页> 外国专利> Rationally-designed meganuclease variants of lig-34 and I-crei for maize genome engineering

Rationally-designed meganuclease variants of lig-34 and I-crei for maize genome engineering

机译：合理设计的lig-34和I-crei的大范围核酸酶变体，用于玉米基因组工程

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摘要

The invention relates to the field of molecular biology and recombinant nucleic acid technology. In particular, the invention relates to a rationally-designed, non-naturally-occurring meganuclease with altered DNA recognition sequence specificity which recognizes and cleaves a unique DNA site in the maize genome. Disclosed herein are meganucleases which are variants of the I-CreI and LIG-34meganucleases. The invention also relates to methods of producing engineered maize plants using such meganucleases.

机译：本发明涉及分子生物学和重组核酸技术领域。特别地，本发明涉及一种合理设计的，具有改变的DNA识别序列特异性的非天然存在的大范围核酸酶，其识别并切割玉米基因组中的独特DNA位点。本文公开的是大范围核酸酶，其是I-CreI和LIG- 34 大范围核酸酶的变体。本发明还涉及使用这种大范围核酸酶生产工程玉米植物的方法。 展开▼

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公开/公告号US8338157B2

专利类型

公开/公告日2012-12-25

原文格式PDF

申请/专利权人 DEREK JANTZ;JAMES JEFFERSON SMITH;
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申请/专利号US20100879428

发明设计人 DEREK JANTZ;JAMES JEFFERSON SMITH;
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申请日2010-09-10

分类号C12N9/22;C07K14/00;

国家 US

入库时间 2022-08-21 16:44:35

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1. 具有经修饰的特异性的I-CreI大范围核酸酶变体、其制备方法及应用 [P] . 中国专利： CN101198694B . 2013.04.10

2. 具有经修饰的特异性的I－CreI大范围核酸酶变体、其制备方法及应用 [P] . 中国专利： CN101198694A . 2008-06-11

3. RATIONALLY-DESIGNED MEGANUCLEASES FOR MAIZE GENOME ENGINEERING [P] . 美国专利： US2011113509A1 . 2011-05-12

机译：玉米基因组工程合理设计的酶

4. RATIONALLY-DESIGNED MEGANUCLEASES FOR MAIZE GENOME ENGINEERING [P] . 世界知识产权组织专利： WO2009114321A3 . 2010-02-04

机译：玉米基因组工程合理设计的酶

5. RATIONALLY-DESIGNED MEGANUCLEASES FOR MAIZE GENOME ENGINEERING [P] . 世界知识产权组织专利： WO2009114321A8 . 2009-12-17

机译：玉米基因组工程合理设计的酶

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4. Understanding the indirect DNA read-out specificity of I-CreI Meganuclease [J] . Jesús Prieto, Pilar Redondo, Blanca López-Méndez, Scientific reports. . 2018,第1期

5. The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy. [J] . S Arnould, C Delenda, S Grizot, Protein engineering design & selection: PEDS . 2011,第1a2期

6. The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy [J] . J. Smith Protein Engineering, Design and Selection . 2011,第1a2期

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8. Defining Genetic and Environmental Determinants of Elemental Homeostasis in Maize (Zea mays L.): A Genome-Wide Association Study of Elemental Composition of Maize Grain [D] . Kear, Philip J. 2018

9. Understanding the indirect DNA read-out specificity of I-CreI Meganuclease [O] . Jesús Prieto, Pilar Redondo, Blanca López-Méndez, -1

10. The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy [O] . S. Arnould, C. Delenda, S. Grizot, 2010

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