Spiro compounds having stearoyl-CoA desaturase action

摘要

The present invention aims to provide a novel SCD inhibitor.;The present invention relate to SCD inhibitor comprising A compound represented by the formula (I); whereinR is an optionally substituted cyclic group or an optionally substituted carbamoyl group, provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl group;ring A is an optionally further substituted pyridazine ring;R₁, R₂, R₃, R₄, R₁₁, R₁₂, R₁₃ and R₁₄ are each independently a hydrogen atom or a substituent, or R₁ and R₁₁ in combination, R₂ and R₁₂ in combination, R₃ and R₁₃ in combination, or R₄ and R₁₄ in combination optionally form an oxo group, or R₂ and R₄ in combination optionally form a bond or an alkylene cross-linkage;m and n are each independently an integer of 0 to 2;ring B is an optionally substituted ring, provided that the two atoms constituting ring B, which are adjacent to the spiro carbon atom, are not oxygen atoms at the same time,or a salt thereof, or a prodrug thereof.