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Synthesis and anti-proliferative effect of substituted imidazo4,5-bpyrazine compounds
Synthesis and anti-proliferative effect of substituted imidazo4,5-bpyrazine compounds
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机译:取代的咪唑并[4,5-b]吡嗪化合物的合成及抗增殖作用
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摘要
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. In particular, the disclosure provides for substituted imidazo[4,5-b]pyrazine compounds having the general formula; their salts, pharmaceutical compositions, and methods of treatment using the subject compounds and compositions.
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