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Compositions and methods for the treatment of sepsis and other disorders involving phospholipase A₂induction

机译：用于治疗败血症和其他涉及磷脂酶A _{2 诱导的疾病的组合物和方法}

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The present invention provides antisense oligomers to PLA₂to inhibit PLA₂protein expression and enzyme activity, and to treat diseases and disorders associated with induced expression of PLA₂. In particular, the invention provides for the simultaneous inhibition of cPLA₂and sPLA₂.

机译：本发明提供了针对PLA _{2 的反义寡聚物，以抑制PLA _{2 的蛋白质表达和酶活性，并治疗与PLA _{2 < / Sub>。特别地，本发明提供了对cPLA _{2 和sPLA _{2 的同时抑制。}}}}}

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公开/公告号US8367816B2

专利类型
公开/公告日2013-02-05

原文格式PDF
申请/专利权人 MAW-SHUNG LIU;
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申请/专利号US201013265842
发明设计人 MAW-SHUNG LIU;
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申请日2010-03-25
分类号C07H21/04;A61K48;
国家 US
入库时间 2022-08-21 16:42:49

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Compositions and methods for the treatment of sepsis and other disorders involving phospholipase A2 induction

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Compositions and methods for the treatment of sepsis and other disorders involving phospholipase A₂induction