Antibody Drug Conjugates against 5T4 Antigen expressed in tumor initiating Cells

摘要

It describes the combination of anti-5t4-drug antibodies and the method of preparing and using them. In some ways, the drug is a headset like MMAF, MMAE. The current antibody drug conjugates bind to tumor cells expressing 5T4 antigen and provide sufficient cytotoxic drugs for cells by providing cancer treatment. 1. Claim 1: a group of antibodies in the formula: ab - (lu-d) 8346; or a salt acceptable in medicine; a) AB is an anti-5T4 antibody or part of one of the antigens,It includes a variable area in the heavy chain, as shown in SEQ ID No.5, including: (1) a VH CDR1 area, (2) a VH CDR2 area, as shown in SEQ ID No.6, and (3) a VH CDR3 area, as shown in SEQ ID No.7; (b) Lu is a paired unit selected from this group, consisting of maleimetropiro and maleimetropilo Val CIT; (c) P is an integer of about 1 to 8; (d) d is a pharmacological unit selected from this group, consisting of MMAE, MMAD and MMAF.