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摘要

Isolated antibodies, compositions, methods of production of antibodies and the use of therapeutically effective amount of antibodies. They are provided with the antibody or antigen binding domains that bind to these polypeptides.Also are provided methods of obtaining antibody that connects the receptor 2 (TR 2) the ligand induction of apoptosis is related to the tumor necrosis factor (TNF) (TRAIL) which comprise administering at least one of these polypeptides to an animal and obtaining an antibody that binds to the TRR - 2 From the animal.There are provided antibodies reactive with tr - 2, pharmaceutical compositions comprising antibodies reactive with tr - 2, pharmaceutical compositions comprising antibodies reactive with tr - 2, methods that use antibodies reactive with tr - 2 and kits comprising antibodies reactive with tr - 2.Also are provided methods for reducing or preventing binding of an antibody to tr 2, managing this polypeptide.