Preparation method of derivatives 3 - rented or C - alkylated from 2-hydroxy - 1,4 - naftoquinonas and analogues and preparation of lapachol

摘要

Preparation method of derivatives 3 - rented or C - alkylated from 2-hydroxy - 1, 4 - naftoquinonas and analogues and preparation of lapachol.The present invention relates to a method for the preparation of alkylated derivatives 3 - or C - alkylated from 2-hydroxy - 1,4 - naftoquinonas and analogues and by means of this method the preparation of the natural product lapachol is the main intermediary to obtain the natural naphthoquinone 2 25 lapachona - (3,4 - diidro - 2, 2 - dimethyl 2H naphtho [1,2-b] Piran - 5.6 - Dione).This method of preparation of derivatives of 3 - rented or C - alkyl of 2 - hydroxy - 1,4 - naftoquinonas by reaction of reduction with formic acid to quinone metu00eddios generated by condensation with aldeidos (R ~ 5 ~ - CHO) in good chemical yields.In this patent application, we describe the results found for the preparation of various products obtained from type 1 or 2 - hydroxy - 1,4 - naftoquinonas replaced in position 3, including the natural product lapachol. The results indicated that the formic acid was effective in the reduction of quinones metu00eddios generated in the reaction medium.The structures of the products were confirmed by physical methods of analysis, with emphasis on the NMR of ^ 1 ^ H.