Binding proteins comprising a modified Repeat domain of anquirina polyethylene glycol and a rest of at least 5 kDa Molecular Weight, Pharmaceutical composition comprising such protEINA Union; use of this Protein for treating pathologic angiogenesis.

摘要

The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.