首页> 外国专利> Method for determining the efficiency of the treatment with interferon beta (IFN beta) in a subject with esclerosismultiple that includes determining at least one gene expression regulated by interferon(IRG) and / or its variant

Method for determining the efficiency of the treatment with interferon beta (IFN beta) in a subject with esclerosismultiple that includes determining at least one gene expression regulated by interferon(IRG) and / or its variant

机译:确定多发性硬化症患者中用干扰素β(IFN beta)治疗的效率的方法,包括确定至少一种受干扰素(IRG)和/或其变体调节的基因表达

摘要

A method is provided for determining the efficacy of interferon-beta (IFN-) therapy in a subject with multiple sclerosis. One step of the method can include obtaining a biological sample from the subject. After obtaining the biological sample, the expression level of at least one interferon-regulated gene (IRG) and/or variant thereof can be determined. Increased or decreased expression of the at least one IRG and/or variant thereof as compared to a control may indicate that the subject will respond poorly to IFN- therapy.
机译:提供了一种用于确定干扰素-β(IFN-)疗法在患有多发性硬化的受试者中的功效的方法。该方法的一个步骤可以包括从受试者获得生物样品。在获得生物样品之后,可以确定至少一种干扰素调节基因(IRG)和/或其变体的表达水平。与对照相比,至少一种IRG和/或其变体的表达增加或减少可表明该受试者对IFN疗法的反应较差。

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