Glucagon Analogue Compound comprising substitutions of amino acid residues in positions 3 and / or 4 which has activity in native glucagon and Glucagon Receptor and / or the receiverGlp-1, Pharmaceutical composition comprising the compound; the use of compound to prevent Weight gain or to promote weight loss in a subject in need.

摘要

The invention provides materials and methods for promoting weight loss or preventing weight gain and for treating diabetes and associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptide compounds effective in such methods. The compounds may mediate their effect by having, for example, increased selectivity for the GLP-1 receptor compared to human glucagon.