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Process for preparing 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one (Aprepitant) in polymorphic form II
Process for preparing 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one (Aprepitant) in polymorphic form II
predlozenu00e9 solving concerns the way of production of aprepitant formula 1, in zu00e1danu00e9 crystal form ii or i,while allowing intermediu00e1t patterns 12 is extracted into the water nemu00edsitelnu00e9ho high temp rozpoustedla selected from alcoholthe ester or ketone, and after washing with water and / or brine solution zahru00edvu00e1 to boiling of the rozpoustedla when there are cyklizaci to aprepitant, and after cooling the aprepitant isoluje.
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