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Inhibitory antibodies that bind the complex of urokinase-type plasminogen activator (uPA) and its receptor (uPAR)
Inhibitory antibodies that bind the complex of urokinase-type plasminogen activator (uPA) and its receptor (uPAR)
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机译:结合尿激酶型纤溶酶原激活物(uPA)及其受体(uPAR)的复合物的抑制性抗体
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摘要
Antibodies or other ligands specific for the binary uPA-uPAR complexes, for ternary complexes comprising uPA-uPAR and for complexes of uPAR and proteins other than uPA such as integrins inhibit the interaction of uPA and uPAR with additional molecules with which the complexed interact. Such antibodies or other ligands are used in diagnostic and therapeutic methods, particularly against cancer.
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