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Aerosolized phosphomycin / tobramycin combination for the treatment of cystic fibrosis
Aerosolized phosphomycin / tobramycin combination for the treatment of cystic fibrosis
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机译:气雾化磷酸霉素/妥布霉素联合治疗囊性纤维化
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摘要
A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 µ, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler.
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