FULL-DIMENSIONAL IGG ISOTYPE IMMUNOGLOBULINS, CAPABLE TO RECOGNITION OF NEUTRALIZING EPITOPE IN THE REGION OF THE HEMAGGLUTININ STEM OF VARIOUS SUBTIPS, AND THEIR USE IN THE QUALITY OF THE VARIABLES OF THE DIFFERENT SUBTYPES, AND THEIR USE AS A VARIETY OF THE STEM

摘要

The invention relates to monoclonal antibodies, which are full-sized immunoglobulins of the IgG isotype, characterized by a very wide spectrum of neutralizing activity against influenza A virus and capable of recognizing a specific hemagglutinin epitope, i.e. highly conserved in various subtypes of influenza A. In addition, the therapeutic, prophylactic and diagnostic uses of the full-length IgG of the invention are described.