PROTEIN-POLYMER CONJUGATES AND METHOD FOR TREATING HEPATITIS B VIRUS OR HEPATITIS C VIRUS INFECTION

摘要

This invention relates to protein-polymer conjugates of formula I; ;wherein each of R₁, R₂, R₃, R₄, and R₅, independently, is H, C_1-5alkyl, C_2-5alkenyl, C_2-5alkynyl, aryl, heteraryl, C_3-8cycloalkyl, or C_3-8heterocycloalkyl; each of A₁ and A₂, independently, is polyethylene glycol; each of G₁, G₂, and G₃, independently, is a bond or a linking functional group; P is a protein moiety; m is 0 or an integer of 1-10; and n is an integer of 1-10. Also disclosed are a method for preparing a protein-polymer conjugate and its use in treating hepatitis B virus or hepatitis C virus infection.