POLYMORPH OF ACID 4-2-4-1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOLE-2-IL-1-PIPERIDINYLETHYL- α, α-DIMETHYL-BENZENEACETIC

摘要

Polymorph 1 of bilastine of the formula (I), which the X-ray crystallographic analysis has the following crystal parameters: crystallographic system: monoclinic; spatial group: P2(1)/c; crystal size: 0.56 x 0.45 x 0.24 mm; cell dimension: a = 2.338 (5) alpha = 90ø, b = 0.8829 (17) nm beta = 90ø, c = 1.259 (2) nm gamma = 90ø; volume 2.6 nm3; Z, calculated density 4, 1.1.84 mg m-3. A process for preparing the polymorph that consists in heating the raw bilastine or polymorphs 2 and 3 of bilastine or a mixture thereof in a solvent selected from short chained alcohols, preferably isopropylic alcohol and n-butanol, acetone and mixtures thereof. The polymorph 1 of bilastine is suitable for antihistaminic and antiallergic use. A pharmaceutical preparation containing this polymorph.