Composition comprising an antibody that binds aminophospholipid and a selected antiviral agent or an antiviral immunocongugate thereof and an antibody that binds aminophospholipid for use in treating or preventing viral infection or disease

摘要

Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.