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Ceramide derivatives as modulators of immunity and autoimmunity
Ceramide derivatives as modulators of immunity and autoimmunity
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机译:神经酰胺衍生物作为免疫和自身免疫的调节剂
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摘要
-Galactosylceramides and glycosylceramides (ceramide-like glycolipids) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the compounds to NK T cells. Pharmaceutical compositions of the ceramide-like glycolipids are provided, as are pharmaceutical compositions of the ceramide-like glycolipids combined with dendritic cells. Methods utilizing the ceramide-like glycolipids in vaccines, to activate NK T cells, to stimulate the immune system, and to treat mammals are also provided. The invention also provides methods of evaluating a compound for its ability to activate an NK T cell in the presence of a cell expressing a CD1d protein.
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