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RECOMBINANT REPLICATION-DEFECTIVE ADENOVIRUS COMPRISING A RECOMBINANT HEXON PROTEIN IN WHICH HYPERVARIABLE REGION SEQUENCES HAVE BEEN REPLACED BY OTHER SEQUENCES
RECOMBINANT REPLICATION-DEFECTIVE ADENOVIRUS COMPRISING A RECOMBINANT HEXON PROTEIN IN WHICH HYPERVARIABLE REGION SEQUENCES HAVE BEEN REPLACED BY OTHER SEQUENCES
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机译:包含高变区序列的其他序列取代的包含重组六邻体蛋白的重组复制缺陷型腺病毒
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摘要
The present invention relates to recombinant adenoviral vectors based on adenoviruses that encounter pre-existing immunity in a minority of the human population and which harbor a chimeric capsid. The chimeric capsid comprises fiber proteins that have at least the knob domain of a human adenovirus that binds to the Coxsackievirus and Adenovirus Receptor (CAR) and a hexon protein from an adenovirus serotype that encounters pre-existing immunity in a low percentage of the human population.
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