(S)-2-{(2R,3R,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-4-FLUORO-3-HYDROXY-4-METHYL-TETRAHYDROFURAN-2-YLMETHOXY-PHENOXY-PHOSPHORYLAMINO}-PROPIONIC ACID ISOPROPYL ESTER OR A STEREOISOMER THEREOF, (S)-ISOPROPYL 2-(((S)-((2R,3R,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-YL)METHOXY)(PHENOXY)PHOSPHORYL)AMINO)PROPANOATE, A METHOD OF SYNTHESIZING THE NUCLEOTIDES AND USES THEREOF

摘要

Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing the compounds represented by formula I.