A METHOD OF REDUCING LEVELS OF SEX STEROID HORMONES IN MAMMALS BY USING RECOMBINANT ANTI-LHRH VACCINES

摘要

:The present invention relates to oligonucleotide sequences of SEQ JD Nos. 1 and 2, and polypeptide sequences of SEQ ID No. 3 and4, useful for preparing recombinant anti-LHRH DNA and proteinic vaccines; also, a method of obtaining the vaccines usingoligonucleotide sequence of SEQ ED No. 1 or 2; further, the vaccine compositions comprising DNA and/or proteinic vaccinesoptionally along with an adjuvant and/or delivery system; and lastly, a method of reducing levels of sex steroid hormones by elicitingan effective antibody response against LHRH in mammals of both sexes using the vaccine compositions, for controlling and/ ortreating the sex-steroid hormone dependent benign prostate hypertrophy and/or prostate cancer, breast cancer, estrus of companionanimals, or meat quality of male animals.No. of Pages : 39 No. of Claims : 35