A BIOACTIVE EXTRACT OF CURRY LEAF (MURRAY KOENIGII) FOR TREATMENT OF PC - 12 CELLS

摘要

The present invention relates to a bioactive extract of curry leaf (Murraya koenigii) for the prevention and treatment affected PC-12 cells exposed to neurotoxic shock. The two different extracts (aqueous and alcohol) prepared from curry leaves are subjected to enzyme assays ie. Catalase, Gpx & SOD, nonenzymatic antioxidant, GSH and lipid peroxidation parameters in PC-12 cells treated with neurotoxic drug 6-hydroxydopamine. The alcohol extracts of curry leaf is found to be more potent than aqueous extracts in offering neuroprotection as indicated by higher levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (Gpx) and lesser lipid peroxidation in PC-12 cells treated with alcohol extracts as compared to cells treated with aqueous extracts. The natural extract prepared from the curry leaf acts as a potential source of neuroprotective agents and it can be extremely valuable in the development of neuroprotective therapies.