A SMART BIOPOLYMER FROM ELEUSINE CORACANA FOR COLON-SPECIFICITY AND ITS OTHER PHARMACEUTICAL APPLICATIONS

摘要

The present invention explains the novelistic approach for colon-specificity coprising of bio-solid dispersion, chips of bio-sustained tablets, bio-hydrogels and other co-processing agents using a novel biopolymer isolated from Eleusine coracana by simple and economic process as a colon-specific retardable polymer. The biopolymer is screened for its physicochemical properties and its in-built properties along with acute toxicity profile. This novelistic approach displayed significantly prolonged release with t80% of 165 hour in colonic pH. The biopolymer displayed its in-built properties like retardability, emulasifiability, sustainability and prolongability which was confirmed by suitably formulating dosage form using beclomethasone as an active pharmaceutical ingredient. Finally conclusion was drawn that chips n" cap is effective technology for colon-specificity should comprise above mentioned composition with biomaterial of Eleusine coracana as a bio-retardant. This novel biomaterial can also serve as bio-compatible excipient to formulate drug loaded drug delivery system.