A NOVEL MINOXIDIL BIONIOSOMES USING SANTALUM ALBUM POLYMER AS A BIOVESICLE FORMING AGENT.

摘要

In recent years, biodegradable polymer materials (known as biocomposites) have gained particular interest specially in Pharma field. Bio-polymers are continually being employed in an expanding range of areas. As a result, many researchers are keen to modify natural materials to make them more user-friendly, and into designing novel polymer composites out of naturally occurring materials. It is suggested that biodegradable polymer materials will reduce the need for synthetic polymer production at a low cost, thereby producing a positive effect both environmentally and economically. We current expose a method for formulating bioniosomes using a biosurfactant which was isolated from santalum album wood. The biopolymer revealed its inbuilt functional groups containing NH2, CH2-, CH3-, CN- and CH2-CH=0 as a functional groups. The niosomes were formulated by modified thin film hydration and sonication method. The niosomes showed a size range of 171-995nm with a promising stability. The biopolymer also revealed other inbuilt novelistic property bio-Retardability, Emulsifiability and Filmability, which was confirmed by suitably formulating drug delivery dosage forms. Conclusion was drawn that bioniosomes can be used for effectively targeting the drug to the hair follicles and niosomes can be prepared by a novel bio-excipient from santalum album and the biopolymer can also serve as a bio-excipient for formulating various drug delivery dosage forms. This present paper is intended to provide a novel method for extraction of the bio-material from natural source & employ it for various pharmaceutical purposes.