A NOVEL SURFACE-FUNCTIONALIZED ZNO-NANOPARTICLES EXHIBITING THERAPEUTIC PROPERTIES, AND PROCESS FOR PREPARING THE SAME'.

摘要

In recent times multidrug resistant microorganisms are being encountered with quite often, both in developed and developing countries, and India is no exception. A sustained search for an effective answer had led to novel surface-functionalized ZnO nanoparticles which have shown considerable promise to combat such microorganisms, and also to act as anti-tumor and anti-bacterial agents. The present invention relates to novel surface-functionalized ZnO nanoparticles (NPs) exhibiting therapeutic properties, characterized in that ZnO quantum dots (QDs) are surface modified or functionalized by capping with capping agents selected from, inter alia, (i) silane or derivatives thereof, (ii) amine terminated silane; (iii) mercapto - or thiol - terminated silane, (iv) thiols or compounds with mercapto group such as acid terminated thiols, mercapto succinic acid, mercaptoundecanoic acid, amine- terminated thiol and 4-aminothiophenol; (v) polymeric bodies like polyethyleneglycol (PEG), polyethyleneimine (PEI), polyvinylalcohol (PVA) and polyvinylpyrrolidone (PVP); (vi) oleic acid; (vii) chitosan; (viii) flourescein isothiocyanate (FITC) and biotin or NHS-biotin. The subject invention is also concerned with a process for preparing the above novel compounds. Figures 1 - 3 of the accompanying drawings illustrate the invention.