SMALL INTERFERING RNA NANOCONSTRUCTS FOR CHEMOSENSITIZATION IN THE TREATMENT OF LUNG CANCER.

摘要

Present investigation deals with development of novel small interfering RNA nanoconstructs for the chemosensitization of Gemcitabine. Lipid based non-viral delivery vectors can be utilized to develop siRNA encapsulated nanoconstructs. Ribonucleotide Reductase subunit-1 (RRM1), a gene responsible for chemoresistance of Gemcitabine, can be targeted using RRMlsiRNA to suppress the expression of this gene. In-vitro cell line evaluation in lung carcinoma cell lines can be utilized to confirm the efficacy of prepared nanoconstructs. In-vivo studies in T-cell suppressed mice can be performed to assess the performance of prepared nanoconstructs.