AN IMPROVED SYNTHESIS OF (3R,4R)-4-ACETOXY-3-(1'R-TERT-BUTYLDIMETHYLSILYOXYETHY1 AZETIDIN-2-ONE, A KEY INTERMEDIATE FOR PENEM AND CARBAPENEM SYNTHESIS

摘要

Abstract: The present invention relates to a novel process for stereoselective synthesis of (3R54R)-4-Acetoxy-3-[1,(R)-tert-Butyldimethylsilyloxyethyl] azetidin-2-one (3), which is a key intermediate in the preparation of Penem and Carbapenem type p-lactam antibiotics. According to the present invention the objective compound can be synthesized using the Camphorsultam as a key and recyclable chiral auxiliary.