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GADOBUTROL PREPARATION IN A ONE-POT PROCESS BY MEANS OF DMF ACETAL AND N-METHYLIMIDAZOLE.
GADOBUTROL PREPARATION IN A ONE-POT PROCESS BY MEANS OF DMF ACETAL AND N-METHYLIMIDAZOLE.
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机译:通过DMF缩醛和N-甲基咪唑在一锅过程中制备GADOBUTROL。
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摘要
A process is described for preparation of the gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl- 1,4,7,10-tetraazacyclododecane "gadobutrol = Gadovist®" in a one-pot process by means of DMF acetal and N-methylimidazole. Gadovist is a gadolinium-containing contrast agent for nuclear spin tomography and has been approved since 2000 in Germany in the indication "contrast amplification in cranial and spinal magnetic resonance tomography".
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