USE OF SUBSTITUTED CYANOPYRROLIDINES FOR THE MANUFACTURE OF MEDICAMENTS FOR TREATING HYPERLIPIDEMIA AND ASSOCIATED DISEASES

摘要

Disclosed are methods and compositions for the treatment of hyperlipidemia and conditions associated therewith, such as CHD, ischemic stroke, restenosis after angioplasty, peripheral vascular disease, intermittent claudication, myocardial infarction (e.g. necrosis and apoptosis), dyslipidemia and post-prandial lipemia. The methods include administration of a therapeutically effective amount of a compound of formula I wherein R is substituted adamantyl; and N is 0 to 3; in free form or in acid addition salt form, and a pharmaceutically acceptable carrier.