Genetic variants for schizophrenia risk assessment

摘要

590832 Disclosed is a method of determining a susceptibility to a schizophrenia condition in a human individual, the method comprising: analyzing nucleic acid sequence information about a human individual and identifying the chromosome 15q11.2 deletion that includes markers rs8040193 and rs3883043 in the genome of the individual, wherein the presence and absence of the chromosome 15q11.2 deletion are associated with different susceptibilities to the condition in humans, and determining a susceptibility to the condition for the individual from the nucleic acid sequence data. Disclosed is a computer program for determining a genetic indicator for a schizophrenia condition in a human individual: wherein the computer program is adapted to be executed on the processor to analyze information about the chromosome 15q11.2 deletion that includes markers rs8040193 and rs3883043, and generate an output based on the information about the chromosome 15q11.2 deletion, wherein the output comprises a risk measure of the chromosome 15q11.2 deletion as a genetic indicator of the schizophrenia condition for the human individual.